SELECT 
  product_prices.product_id, 
  MIN(
    IF(
      product_prices.percentage_discount = 0, 
      product_prices.price, 
      product_prices.price - (
        product_prices.price * product_prices.percentage_discount
      )/ 100
    )
  ) AS price 
FROM 
  product_prices 
WHERE 
  product_prices.product_id IN (
    486878, 486885, 487402, 488167, 488178, 
    488180, 488186, 488719, 489519, 490021, 
    490025, 490034
  ) 
  AND product_prices.lower_limit = 1 
  AND product_prices.usergroup_id IN (0, 1) 
GROUP BY 
  product_prices.product_id

Query time 0.00174

JSON explain

{
  "query_block": {
    "select_id": 1,
    "cost_info": {
      "query_cost": "8.75"
    },
    "grouping_operation": {
      "using_filesort": false,
      "table": {
        "table_name": "product_prices",
        "access_type": "range",
        "possible_keys": [
          "usergroup",
          "product_id",
          "lower_limit",
          "usergroup_id"
        ],
        "key": "product_id",
        "used_key_parts": [
          "product_id"
        ],
        "key_length": "3",
        "rows_examined_per_scan": 12,
        "rows_produced_per_join": 1,
        "filtered": "10.00",
        "index_condition": "(`goimagine`.`product_prices`.`product_id` in (486878,486885,487402,488167,488178,488180,488186,488719,489519,490021,490025,490034))",
        "cost_info": {
          "read_cost": "8.63",
          "eval_cost": "0.12",
          "prefix_cost": "8.75",
          "data_read_per_join": "28"
        },
        "used_columns": [
          "id",
          "product_id",
          "price",
          "percentage_discount",
          "lower_limit",
          "usergroup_id"
        ],
        "attached_condition": "((`goimagine`.`product_prices`.`lower_limit` = 1) and (`goimagine`.`product_prices`.`usergroup_id` in (0,1)))"
      }
    }
  }
}

Result

product_id price
486878 3.55000000
486885 6.35000000
487402 2.45000000
488167 18.00000000
488178 15.00000000
488180 2.45000000
488186 2.45000000
488719 18.00000000
489519 18.00000000
490021 20.00000000
490025 2.45000000
490034 2.45000000